Our Scientific Research & Clinical Studies

This study, published in Annals of Medical Research[cite: 9], investigated the antimicrobial effects of *Citrus limonum* (lemon) essential oil on microorganisms that cause endodontic infections. The study compared the efficacy of lemon essential oil with traditionally used calcium hydroxide. [cite: 10, 11]

Key Findings:

• Citrus limonum essential oil demonstrated antimicrobial effects against endodontic pathogens. [cite: 10]
• Lemon essential oil produced broader inhibition zones than calcium hydroxide for all microorganisms tested, with particularly strong results against *Candida albicans*. [cite: 28, 29]
• The main component of the Art de Huile Lemon essential oil used in this research was Limonene (73.27%). [cite: 15]
• The study suggests that Citrus limonum essential oil can be considered as an alternative therapy to traditional calcium hydroxide in endodontic pathogen treatments. [cite: 34]

[Link to the full publication if available]

This pilot study, published in the Journal of Immunology and Clinical Microbiology, investigated the effects of *Eucalyptus globulus* (eucalyptus) essential oil on symptoms experienced by patients with post-COVID syndrome. [cite: 38, 39]

Key Findings:

• The study assessed the impact of eucalyptus essential oil on symptoms such as shortness of breath (dyspnea), back pain, and anxiety in post-COVID patients. [cite: 40]
• Statistically significant reductions were observed in dyspnea, back pain, and anxiety scores after treatment with Art de Huile Eucalyptus essential oil. [cite: 53]
• The main component of the Art de Huile Eucalyptus oil used in this research was 1,8-Cineole (Eucalyptol, 73.687%). [cite: 47]
• Eucalyptus oil showed potential in relieving breathlessness (with bronchodilator, antiviral and anti-inflammatory effects), back pain, and anxiety in post-COVID patients. [cite: 54, 55]

[Link to the full publication if available]

This research, published in the International Journal of Computational and Experimental Science and Engineering (IJCESEN), explored the microencapsulation of lemon (*Citrus limon*) and eucalyptus (*Eucalyptus globulus*) essential oils to enhance their stability and effectiveness. [cite: 58, 59, 61, 62]

Key Findings:

• The study successfully microencapsulated lemon and eucalyptus oils using gelatin, gum arabic, and chitosan as coating materials. [cite: 64]
• Microencapsulation was shown to increase the effectiveness of essential oils and protect them from environmental degradation. [cite: 83]
• The process resulted in spherical microcapsules with a homogeneous distribution and stable structure. [cite: 75, 76]
• The research confirmed the chemical composition of the Art de Huile Lemon and Eucalyptus oils used. [cite: 79, 80, 81]

[Link to the full publication if available]

This study, published in the Anatolian Current Medical Journal, investigated the efficacy of *Melaleuca viridiflora* (Niaouli) essential oil in treating urinary tract infections (UTIs) in patients with hemiplegia. [cite: 86, 87, 90]

Key Findings:

• The study showed that Niaouli oil treatment improved laboratory values and clinical symptoms in hemiplegic patients with UTIs. [cite: 107]
• Niaouli oil treatment reduced the need for antibiotics in these patients. [cite: 108]
• The main components of the Art de Huile Niaouli oil used were 1,8-cineol, Terpinen-4-ol, and other monoterpenes. [cite: 97]

[Link to the full publication if available]

This research, published in the Turkish Journal of Agriculture - Food Science and Technology, explored the antimicrobial, anticancer, and cytotoxic activities of *Melaleuca viridiflora* (Niaouli) essential oil. [cite: 109, 112]

Key Findings:

• Niaouli essential oil exhibited strong antibacterial and antifungal effects. [cite: 133]
• The oil showed a strong effect on DU-145 (Prostate cancer) cells and was effective in MCF-7 (Breast Cancer) cells. [cite: 129, 130]
• No toxic effect was observed in WI-38 healthy human fibroblast cells, suggesting a safe area of use. [cite: 131, 134]
• The main components of the Art de Huile Niaouli oil used were 1,8-Cineol, a-Pinene, and Limonene. [cite: 120]

[Link to the full publication if available]

This study investigated the antimicrobial, antitumor, and cytotoxic activities of Palmarosa (*Cymbopogon martinii*) and Niaouli (*Melaleuca viridiflora*) essential oils. [cite: 138, 139]

Key Findings:

• Palmarosa oil showed the highest activity against *Bacillus cereus* and was moderately effective against *Candida albicans* and *Klebsiella pneumoniae*. [cite: 147]
• Niaouli oil had a moderate effect on *Bacillus cereus*. [cite: 147]
• Both Palmarosa and Niaouli oils showed potential as anticancer agents, exhibiting cytotoxic effects on prostate and breast cancer cells. [cite: 155]
• Neither oil showed toxicity in healthy human cells. [cite: 152]

[Link to the full publication if available]

This research, published in the Journal of Food Quality, examined the effects of lavender oil aromatherapy on the quality of life in patients with fibromyalgia. [cite: 157, 159]

Key Findings:

• Lavender oil aromatherapy significantly improved all subscales of the SF-36 Quality of Life Scale (except general health) in fibromyalgia patients. [cite: 169]
• Significant improvements were observed in physical functioning, mental health, social functioning, and pain subscales. [cite: 170]
• The main components of the Art de Huile Lavender oil used were Linalool (29.33%) and Linalyl Acetate (27.69%). [cite: 167]

[Link to the full publication if available]

This study evaluated the effects of inhaled lavender (*Lavandula officinalis*) and frankincense (*Boswellia*) oils on pain and anxiety in patients undergoing shock wave lithotripsy (SWL). [cite: 180, 181, 182]

Key Findings:

• Both lavender and frankincense oils reduced anxiety more effectively than the placebo group. [cite: 188]
• Frankincense oil showed a more significant reduction in anxiety compared to lavender oil. [cite: 189]
• The main components of the Art de Huile Lavender oil used were Linalool and Linalyl Acetate, while the main constituents of Frankincense oil were Boswellic acids. [cite: 185, 186]

[Link to the full publication if available]

This research investigated the effects of inhaled ylang-ylang (*Cananga odorata*) and lemon (*Citrus limon*) essential oils on labor pain and anxiety during the active phase of labor. [cite: 192, 193]

Key Findings:

• Inhalation of lemon oil and ylang-ylang oil reduced labor pain at 5-7 cm cervical dilatation compared to the control group. [cite: 204, 208]
• The main components of the Art de Huile Lemon oil were analgesic, antidepressant and anti-inflammatory, while the main components of Ylang Ylang oil were relaxing, sedative and stress-reducing. [cite: 201, 202]

[Link to the full publication if available]

This study investigated the antibacterial and antibiofilm effects of Niaouli, Palmarosa, and Clove essential oils on *Pseudomonas aeruginosa*, Methicillin Resistant *Staphylococcus aureus* (MRSA), and other *Staphylococcus* spp. bacteria isolated from dog wounds. [cite: 212, 213]

Key Findings:

• Palmarosa oil showed the highest antibacterial effect on *Staphylococcus* spp. [cite: 222]
• Clove oil provided the highest biofilm inhibition in reference MRSA strains. [cite: 225]
• All oils demonstrated cell viability in canine fibroblast cells. [cite: 226]
• The main component of Palmarosa oil was Geraniol (84.152%), Niaouli oil was 1,8-Cineol (70.382%), and Clove oil was Eugenol (88.013%). [cite: 218, 219, 220]

[Link to the full publication if available]

This research evaluated the potential therapeutic effects of essential oils in a 48-year-old male patient with Attention Deficit and Hyperactivity Disorder (ADHD). [cite: 236, 237]

Key Findings:

• NoseMix exhibited an acetylcholinesterase (AChE) inhibitory effect, potentially enhancing communication between nerve cells. [cite: 239]
• The formulation increased protein expression related to the dopamine receptor, potentially boosting dopamine production. [cite: 240]
• NoseMix regulated and enhanced reward, motivation, mood, motor control, and cognitive functions. [cite: 243]

[Link to the full publication if available]

This publication in Pharmaceuticals explored the effects of certain probiotics in coconut oil (COCOBIOTIC) on microbiota, gastrointestinal diseases, and especially SIBO (Small Intestinal Bacterial Overgrowth). [cite: 253, 255]

Key Findings:

• Poor nutrition and resulting dysbiosis (microbiome imbalance) were identified as significant risk factors for SIBO development. [cite: 258, 259]
• Oils, even when used alone, positively influenced microbiota diversity, balancing and increasing it. [cite: 261, 262]
• Probiotics showed positive effects in regulating the microbiota. [cite: 263]
• The combination of oils and probiotics (Cocobiotic) enhanced the effectiveness of probiotics, with oils acting as carriers to the colon. [cite: 264, 265, 266, 267]
• Cocobiotic demonstrated therapeutic effects by increasing diversity and preventing/treating dysbiosis. [cite: 268, 269]

[Link to the full publication if available]

This international research collaboration investigated the antiviral properties of Clove, Palmarosa, and Niaouli essential oils on Human Papillomavirus (HPV) infection. [cite: 330, 331, 332]

Key Findings:

• Essential oil molecules, including β-caryophyllene, Geranyl acetate, Geraniol, and Nerol, were analyzed for their Anti-HPV IC50 values. [cite: 335]
• A special formulation (F9) combining Clove, Palmarosa, and Niaouli oils was developed. [cite: 336, 341]
• The oils demonstrated anti-HPV effects by modulating and inhibiting the E7 and E2 protein pathways. [cite: 337]
• The essential oils and F9 formulation showed antiviral efficacy against several HPV strains, particularly HPV types 2, 6, 16, and 18. [cite: 361]
• The formulation showed potential in reducing the cancer risk associated with oncogenic HPV types 16 and 18. [cite: 364]

[Link to the full publication if available]

This study evaluated the effects of lavender, marjoram, and vetiver essential oils on the masseter muscle in patients with bruxism (teeth grinding). [cite: 367]

Key Findings:

• While objective measurements using ultrasonography didn't show significant differences, patients reported subjective improvements. [cite: 373, 375]
• Patients in the aromatherapy group reported better sleep and reduced pain levels. [cite: 375, 376]
• The essential oil blend used included marjoram, lavender, and vetiver oils. [cite: 378]

[Link to the full publication if available]